A novel XRF method to measure environmental release of copper and zinc from antifouling paints

Ytreberg E; Lagerström M.; Holmqvist A.; Eklund B.; Elwing H.; Dahlström M.; Dahl P.; Dahlström M.
2017 | Environ. Pollut. | 225 (490-496)

Provningsjämförelse / Proficiency Test 2017-2, Suspenderade ämnen och slam/ Suspended solids and sludge

2017 | ACES rapport, Department of Environmental Science and Analytical Chemistry, Stockholm University | Report No: 18

Modelling exposure to ionizing substances with spatial and temporal resolved models: A case study for multiple pharmaceuticals in the Baltic area

Lindim, C.; van Gils, J.; Cousins, I.T.; Kuhne, R.; Kutsarova, S.; Mekenyan, O.
2017 | Society of Environmental Toxicology and Chemistry (SETAC)

SETAC Europe 27th Annual Meeting | May 11, 2017 | Brussels, Belgium

Ecological modelling can link chemical exposure to effects on the population dynamics of aquatic invertebrate species for major European rivers

Focks, A.; Baveco, H.; Lindim, C.; Cousins, I.T.; van den Brink, P.
2017 | Society of Environmental Toxicology and Chemistry (SETAC)

SETAC Europe 27th Annual Meeting | May 9, 2017 | Brussels, Belgium

Per- and polyfluoroalkyl substances (PFASs) in individuals’ serum samples over childhood

Winkens, K.; Koponen, J.; Airaksinen, R.; Berger, U.; Vestergren, R.; Cousins, I.T.; Karvonen, A.; Pekkanen, J.; Kiviranta, H.
2017 | Society of Environmental Toxicology and Chemistry (SETAC)

SETAC Europe 27th Annual Meeting | May 8, 2017 | Brussels, Belgium

New Mechanisms in Assessing and Managing Per- and Polyfluoroalkyl Substances? Current Needs and Our Recommendations

Wang, Z.; Cousins, I.T.; Hungerbühler, K.; Scheringer, M.
2017 | Society of Environmental Toxicology and Chemistry (SETAC)

SETAC Europe 27th Annual Meeting | May 8, 2017 | Brussels, Belgium

Decoupling of microbial carbon, nitrogen, and phosphorus cycling in response to extreme temperature events

Mooshammer M.; Hofhansl F.; Frank A.H.; Wanek W.; Hämmerle I.; Leitner S.; Schnecker J.; Wild B.; Watzka M.; Keiblinger K.M.; Zechmeister-Boltenstern S.; Richter A.
2017 | Sci. Adv. | 3 (e1602781)

Relationships between estimated flame retardant emissions and levels in indoor air and house dust

Liagkouridis, I.; Cequier, E.; Lazarov, B.; Palm Cousins, A.; Thomsen, C.; Stranger, M.; Cousins, I.T.
2017 | Indoor Air | 27 (3) (650-657)

Efficient collection and preparation of methane from low concentration waters for natural abundance radiocarbon analysis

K. J. Sparrow; J. D. Kessler
2017 | Limnol Oceanogr Methods

Freshwater and marine environments constitute the largest global reservoirs of the greenhouse gas methane (CH4) and natural abundance radiocarbon measurements (14C-CH4) can allow for high confidence interpretations about CH4 dynamics operating in these environments. Collecting sufficient amounts of CH4 sample for a standard, high precision 14C-accelerator mass spectrometry (AMS) analysis (∼ 200 μg carbon (C)) was previously unfeasible when sampling from low CH4 concentration waters, such as much of the surface ocean (∼ 2 nM), which would require collecting the CH4 from 8500 L of seawater. The method described here involves pumping 20,000–40,000 L of seawater up from depth through a dissolved gas extraction system, which enables the collection of a sample composed of 100s of L of gas in less than 4 h on station. The large volume extracted gas sample is compressed into a 1.7 L cylinder for transport from the ship to the home laboratory. The home laboratory preparation of each sample to a CH4-derived carbon dioxide aliquot for 14C-AMS analysis is carried out in 3 h on a flow-through vacuum line that simultaneously prepares aliquots for stable isotope analyses (δ13C-CH4 and δ2H-CH4). The total process blank of the method is small (5.0 μg CH4-C) and composes 1.2% of the average collected and prepared sample (424 ± 163 μg, from a recent campaign; n = 16). The 14C-CH4 blanks prepared on the vacuum line have acceptably low 14C content (0.23 ± 0.07 percent Modern Carbon (pMC); n = 7) relative to the 14C-dead (0 pMC) CH4 from which they are prepared.

Per- and polyfluoroalkyl substances (PFASs) in San Francisco Bay wildlife: Temporal trends, exposure pathways, and notable presence of precursor compounds

Sedlak, MD; Benskin, JP; Wong, A; Grace, R; Greig DJ.
2017 | Chemosphere

Grain-size dependence of mercury speciation in river suspended matter, sediments and soils in a mercury mining area at varying hydrological conditions

Baptista-Salazar, Carluvy; Richard, Jan-Helge; Horf, Michael; Rejc, Mateja; Gosar, Mateja and Biester, Harald
2017 | Appl. Geochem. | 81 (132-142)

Adductomic Screening of Hemoglobin Adducts and Monitoring of Micronuclei in School-Age Children

Carlsson H.; Aasa J.; Kotova N.; Vare D., Sousa P.; Rydberg, P.; Abramsson-Zetterberg L.; Törnqvist M.
2017 | Chem. Res. Toxicol. | 30 (5) (1157-1167)

Electrophilic compounds/metabolites present in humans, originating from endogenous processes or exogenous exposure, pose a risk to health effects through their reactions with nucleophilic sites in proteins and DNA, forming adducts. Adductomic approaches are developed to screen for adducts to biomacromolecules in vivo by mass spectrometry (MS), with the aim to detect adducts corresponding to unknown exposures from electrophiles. In the present study, adductomic screening was performed using blood samples from healthy children about 12 years old (n = 51). The frequencies of micronuclei (MN) in erythrocytes in peripheral blood were monitored as a measure of genotoxic effect/genotoxic exposure. The applied adductomic approach has been reported earlier by us and is based on analysis of N-terminal valine adducts in hemoglobin (Hb) by liquid chromatography tandem mass spectrometry (LC-MS/MS). High resolution MS was introduced for refined screening of previously unknown N-terminal Hb adducts. Measured adduct levels were compared with MN frequencies using multivariate data analysis. In the 51 individuals, a total of 24 adducts (whereof 12 were previously identified) were observed and their levels quantified. Relatively large interindividual variations in adduct levels were observed. The data analysis (with partial least-squares regression) showed that as much as 60% of the MN variation could be explained by the adduct levels. This study, for the first time, applies the combination of these sensitive methods to measure the internal dose of potentially genotoxic chemicals and genotoxic effects, respectively. The results indicate that this is a valuable approach for the characterization of exposure to chemical risk factors for the genotoxic effects present in individuals of the general population.

Contact information

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Geovetenskapens Hus,
Svante Arrhenius väg 8, Stockholm

Arrheniuslaboratoriet, Svante Arrhenius väg 16, Stockholm (Unit for Toxicological Chemistry)

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Department of Environmental Science
Stockholm University
106 91 Stockholm

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