EQUILIBRIUM CHARGE-DISTRIBUTION OF MULTIPLETS OF MONODISPERSE LATEX SPHERES

AHLBERG, MS; HANSSON, HC
1983 | J Aerosol Sci | 14 (4) (499-505)

A COMPREHENSIVE STUDY OF PHYSICAL AND CHEMICAL-PARAMETERS OF THE ARCTIC SUMMER AEROSOL – RESULTS FROM THE SWEDISH EXPEDITION YMER-80

LANNEFORS, H; HEINTZENBERG, J; HANSSON, HC
1983 | Tellus B Chem Phys Meteorol | 35 (1) (40-54)

Chlorinated Paraffins: Disposition of a polychloro-[1-14C]hexadecane in carp (Cyprinus Carpio) and bleak (Alburnus Alburnus).

Darnerud PO; Bengtsson B; Bergman Å; Brandt I;
1983 | Toxicol. Lett. | 19

BACKGROUND AEROSOL COMPOSITION IN SOUTHERN SWEDEN – 14 MICRO AND MACRO CONSTITUENTS MEASURED IN 7 PARTICLE-SIZE INTERVALS AT ONE SITE DURING ONE YEAR

LANNEFORS, H; HANSSON, HC; GRANAT, L
1983 | Atmos. Environ. | 17 (1) (87-101)

Microsomal and cytosolic epoxide hydrolases: Total activities, subcellular distribution and induction in the liver and extrahepatic tissues

DePierre, J.W.; Meijer, J.; Birberg, W.; Pilotti, Å.; Balk, L.; Seidegård, J.
1983 | Elsevier Science Publishers (95-103) | ISBN: 0-444-80538-9

International Meeting on Extrahepatic Drug Metabolism and Chemical Carcinogenesis | August 17, 2019 | Stockholm, Sweden

Metabolism of 2,4′,5-trichlorobiphenyl: Enrichment of hydroxylated and methyl sulphone metabolites in the uterine luminal fluid of pregnant mice

Brandt I; Darnerud PO; Bergman Å; Larsson Y;
1982 | Chem. Biol. Interact. | 40

Metabolism of 2,4′,5-trichlorobiphenyl: Tissue concentrations of methylsulphonyl-2,4′,5-trichlorobiphenyl in germfree and conventional mice

Brandt I; Klasson Wehler E; Rafter J; Bergman Å;
1982 | Toxicol. Lett. | 12

Metabolism of 2,4′,5-trichlorobiphenyl by the mercapturic acid pathway

Bakke JE; Bergman Å; Larsen GL;
1982 | Science | 217

Preparation and characterization of subcellular fractions from the liver of the northern pike, Esox lucius

Balk, L.; Meijer, J.; Bergstrand, A.; Åström, A.; Morgenstern, R.; Seidegård, J.; DePierre, J.W.
1982 | Biochem. Pharmacol. | 31 (1491-1500)

The present study was designed to prepare and characterize subcellular fractions from the liver of the Northern pike (Esox lucius), with special emphasis on the preparation of microsomal fractions suitable for studying xenobiotic metabolism. The purity of the different fractions obtained by differential centrifugation, as well as the recovery of different organelles, was determined using both enzyme markers and morphological examination with the electron microscope. Attempts were also made to increase the recovery of fragments of the endoplasmic reticulum in the microsomal fraction. Finally, the subcellular distribution of several drug-metabolizing enzymes (cytochrome P-450, benzpyrene monooxygenase, epoxide hydrolase and glutathione transferases) were determined. With the exception of the subcellular distribution of epoxide hydrolase, the results obtained here resemble closely those reported for rat liver and the microsomal fraction prepared is highly suitable for further studies of drug metabolism in pike liver.

Separation of the different classes of conjugates formed by metabolism of benzol[a]pyrene in the northern pike (Esox lucius)

Balk, L.; Knall, A.; DePierre, J.W.
1982 | Acta Chem. Scand., B, Org. Chem. Biochem. | 36 (403-405)

Formation of mutagenic metabolites from benzo(a)pyrene and 2-aminoanthracene by the S-9 fraction from the liver of the Northern pike (Esox lucius): Inducibility with 3-methylcholanthrene and correlation with benzo[a]pyrene monooxygenase activity

Balk, L.; DePierre, J.W.; Sundvall, A.; Rannug, U.
1982 | Chem. Biol. Interact. | 41 (1-13)

The mutagenicity of benzo[a]pyrene and 2-aminoanthracene in the Ames test using the S-9 fraction from the liver of the Northern pike (Esox lucius) was tested. S-9 fractions were prepared both from fish injected intraperitoneally with 3-methylcholanthrene and from control animals. In addition benzo[a]pyrene monooxygenase activity was assayed in the same S-9 fractions used in the Ames test.

S-9 fractions from the liver of the Northern pike were found to convert benzo[a]pyrene and 2-aminoanthracene to mutagenic metabolites. The number of revertants obtained was increased 2–4-fold in the case of 2-aminoanthracene and 3–14-fold in the case of benzo[a]pyrene by pretreatment of the pike with a single intraperitoneal injection of 3-methylcholanthrene. This injection also caused a 2–6-fold increase in the benzo[a]pyrene monooxygenase activity of the S-9 fractions used. These increases in mutagenicity and activity occur mainly during the first 4–12 days after the injection, but further small increases are observed for as long as 60 days.

A strong positive correlation was found between the benzo[a]pyrene monooxygenase activity of the S-9 fractions used and their ability to give rise to revertants in the Ames test using 2-aminoanthracene or benzo[a]pyrene. This indicates that the major determining factor in the production of reactive metabolites which attack DNA in this in vitro system is the activity of the phase I cytochrome P-450 system.

Biliary secretion, retention and excretion of five 14C-labelled polychlorinated biphenyls in the rat

Bergman Å; Larsen GL; Bakke JE;
1982 | Chemosphere | 11

Contact information

Visiting addresses:

Geovetenskapens Hus,
Svante Arrhenius väg 8, Stockholm

Arrheniuslaboratoriet, Svante Arrhenius väg 16, Stockholm (Unit for Analytical and Toxicological Chemistry)

Mailing address:
Department of Environmental Science and Analytical Chemistry (ACES)
Stockholm University
106 91 Stockholm

Press enquiries should be directed to:

Stella Papadopoulou
Science Communicator
Phone +46 (0)8 674 70 11
stella.papadopoulou@aces.su.se