BMAA in shellfish from two Portuguese transitional water bodies suggests the marine dinoflagellate Gymnodinium catenatum as a potential BMAA source

Lage, S; Costa, PR; Moita, T; Eriksson, J; Rasmussen, U; Rydberg, SJ
2014 | Aquat. Toxicol. | 152 (131-138)
beta-n-methylamino-l-alanine (bmaa) , bioaccumulation , cerastoderma edule , cyanobacterial blooms , dinoflagellates , fluorescence detection , gymnodinium-catenatum , harmful algal blooms , liquid chromatography , methylamino-l-alanine , neurotoxic amino-acid , paralytic shellfish toxins , poisoning toxins , portugal , prechromatographic oxidation , quantitative-determination , ria formosa , transitional water bodies
The neurotoxin beta-N-methylamino-L-alanine (BMAA) and its putative role in multiple neurodegenerative diseases have been intensely studied since 2005 when the toxin was discovered to be produced by worldwide-distributed cyanobacterial species inhabiting terrestrial, marine, brackish, and freshwater ecosystems. Recently, BMAA production was also associated with one eukaryotic group, namely, diatoms, raising questions about its production by other phytoplanktonic groups. To test for BMAA bioavailability in ecosystems where abundant phytoplanktonic blooms regularly occur, samples of filter-feeding shellfish were collected in two Portuguese transitional water bodies. BMAA content in cockles (Cerastoderma edule) collected weekly between September and November 2009 from Ria de Aveiro and at least once a month from May to November from Ria Formosa, fluctuated from 0.079 +/- 0.055 to 0.354 +/- 0.066 mu g/g DW and from below the limit of detection to 0.434 +/- 0.110 mu g/g DW, respectively. Simultaneously to BMAA occurrence in cockles, paralytic shellfish toxins were detected in shellfish as a result of Gymnodinium catenatum blooms indicating a possible link between this marine dinoflagellate and BMAA production. Moreover, considerable high BMAA levels, 0.457 +/- 0.186 mu g/g DW, were then determined in a laboratory grown culture of G. catenatum. This work reveals for the first time the presence of BMAA in shellfish from Atlantic transitional water bodies and consubstantiate evidences of G. catenatum as one of the main sources of BMAA in these ecosystems. (C) 2014 Elsevier B.V. All rights reserved.

Reductive debromination of nonabrominated diphenyl ethers by sodium borohydride and identification of octabrominated diphenyl ether products

Granelli, L; Eriksson, J; Athanasiadou, M; Bergman, A
2011 | Chemosphere | 82 (839-846)

Quantitative structure – Photodegradation relationships of polybrominated diphenyl ethers, phenoxyphenols and selected organochlorines

Heimstad, ES; Bastos, PM; Eriksson, J; Bergman, A; Harju, M
2009 | Chemosphere | 77 (914-921)

An improved method for assessing relative nucleophilic substitution reactivities of polychlorinated benzenes

Qiu Y; Eriksson J; Granelli L; Bergman Å;
2009 | Chemosphere | 75

Identification and quantification of products formed via photolysis of decabromodiphenyl ether

Christiansson A; Eriksson J; Teclechiel D; Bergman Å;
2009 | Environ Sci Pollut Res | 16

Oxidative transformation of polybrominated diphenyl ether congeners (PBDEs) and of hydroxylated PBDEs (OH-PBDEs)

Moreira Bastos P; Eriksson J; Vidarson J; Bergman Å;
2008 | Environ Sci Pollut Res Int | 15

A standardized method for assessment of oxidative transfrormations of brominated phenols in water

Moreira Bastos P; Eriksson J; Green N; Bergman Å;
2008 | Chemosphere | 70

Testing and risk assessment of persistent and bioaccumulating chemical substances – Improvements within REACH?

2006 | Hum. Ecol. Risk Assess. | 12 (4) (782-805)
cas 32534-81-9 , constants , contaminants , cytochrome-p450 activity , exposure , harpacticoid copepod , liver morphology , pbdes , pbt , pentabde , reach , reproduction , risk assessment , sediment , vpvb , water

In the proposed new European chemicals regulations - the REACH system - the improved control of persistent and bioaccumulating substances is stated as one of the tasks being of particular importance. In this article, the reliability and validity of the scientific basis for identification of persistent ( P), bioaccumulating ( B), and toxic ( T) substances, and for assessing the risks that these substances may pose, are discussed. We have used the European Union risk assessment of pentabromodiphenyl ether, PentaBDE ( CAS 32534-81-9) as a study case in the analysis. It is concluded that for PBT substances there is room for development both with regard to test methodology and with regard to risk assessment procedures.

Methods for synthesis of nonabromodiphenyl ethers and a chloro-nonabromodiphenyl ether

Christiansson A; Teclechiel D; Eriksson J; Bergman Å; Marsh G;
2006 | Chemosphere | 63

Neonatal exposure to higher brominated diphenyl ethers, hepta-, oct-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory funktions of adult mice

Viberg H; Johansson N; Fredriksson A; Eriksson J; Marsh G; Eriksson P;
2006 | Toxicol. Sci. | 92

Photochemical transformations of tetrabromobisphenol A and related phenols in water

Eriksson J; Rahm S; Green N; Bergman Å; Jakobsson E;
2004 | Chemosphere | 54

Di-p-bromophenyl ether, a redetermined crystal structure derived from low-quality diffraction data

Eriksson L; Eriksson J; Hu J;
2004 | Acta Crystallogr | B60
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