Determination of Chlorinated Paraffins by Bromide-Anion Attachment Atmospheric-Pressure Chemical Ionization Mass Spectrometry

Yuan B, Benskin JP, Chen CL, Bergman Å
2018 | Environ. Sci. Technol. Lett. | In Press

Cats’ Internal Exposure to Selected Brominated Flame Retardants and Organochlorines Correlated to House Dust and Cat Food

Engdahl, JN; Bignert, A; Jones, B; Athanassiadis, I; Bergman, A; Weiss, JM
2017 | Environ. Sci. Technol. | 51 (5) (3012-3020)
Pet cats may be used as a biomarker for assessing exposures to organohalogen compounds (OHCs) adsorbed to household dust in home environments. This study explores two exposure routes of OHCs, ingestion of OHCs (i) via house dust and (ii) via cat food. House dust from 17 Swedish homes and serum from the participating families' pet cats were collected, and cat food was purchased matching the diet reported. Paired samples of cat serum, house dust, and cat food were analyzed for brominated flame retardants/natural products (polybrominated diphenyl ethers (PBDEs), decabromobiphenyl (BB-209), decabromodiphenyl ethane (DBDPE), 2,4,6-tribromophenol (2,4,6-TBP), OH-PBDEs) and organochlorines (polychlorinated biphenyls (PCBs), 1,1-bis(4,4'-dichlorodipheny1)-2,2,2-trichloroethane (4,4'-DDT), 1,1-bis(4,4'-dichlorodiphenyl)-2,2-dichloroethene (4,4'-DDE), hexachlorobenzene (HCB), pentachlorophenol (PCP)). Significant correlations were found between serum and dust samples from the living rooms for BDE-47 (p < 0.035), BDE-99 (p < 0.035), and BDE-153 (p < 0.039), from the adult's bedroom for BDE-99 < 0.019) and from all rooms for BDE-99 (p < 0.020) and BB-209 (p < 0.048). This is the first time a correlation between cat serum levels and household dust has been established, a finding that supports the hypothesis that dust is a significant exposure route for cats. Serum levels were also significantly correlated with concentrations found in cat food for 6-OH-BDE47 (p < 0.002), 2,4,6-TBP (p < 0.035), and BB-209 (p < 0.007). DBDPE was found in high concentrations in all dust (median 154 pmol/g) and food samples (median 0.7 pmol/ig lw) but was below detection in serum samples, suggesting low or no bioavailability for DBDPE in cats.

Extensive organohalogen contamination in wildlife from a site in the Yangtze River Delta

Zhou, YH; Asplund, L; Yin, G; Athanassiadis, I; Wideqvist, U; Bignert, A; Qiu, YL; Zhu, ZL; Zhao, JF; Bergman, A
2016 | Sci. Total Environ. | 554 (320-328)
The environmental and human health concerns for organohalogen contaminants (OHCs) extend beyond the 23 persistent organic pollutants (POPs) regulated by the Stockholm Convention. The current, intense industrial production and use of chemicals in China and their bioaccumulation makes Chinese wildlife highly suitable for the assessment of legacy, novel and emerging environmental pollutants. In the present study, six species of amphibians, fish and birds were sampled from paddy fields in the Yangtze River Delta (YRD) were screened for OHCs. Some extensive contamination was found, both regarding number and concentrations of the analytes, among the species assessed. High concentrations of chlorinated paraffins were found in the snake, Short-tailed mamushi (range of 200-340 mu g g(-1) lw), Peregrine falcon (8-59 mu g g(-1) lw) and Asiatic toad (97 mu g g(-1) lw). Novel contaminants and patterns were observed; octaCBs to decaCB made up 20% of the total polychlorinated biphenyls (PCBs) content in the samples and new OHCs, substituted with 5-8 chlorines, were found but are not yet structurally confirmed. In addition, Dechlorane 602 (DDC-DBF) and numerous other OHCs (DDTs, hexachlorocyclohexanes (HCHs), polybrominated diphenyl ethers (PBDEs), hexbromocyclododecane (HBCDD), chlordane, heptachlor, endosulfan and Mirex) were found in all species analyzed. These data show extensive chemical contamination of wildlife in the YRD with a suite of OHCs with both known and unknown toxicities, calling for further indepth studies. (C) 2016 The Authors. Published by Elsevier B.V.

Higher PBDE Serum Concentrations May Be Associated with Feline Hyperthyroidism in Swedish Cats

Norrgran, J; Jones, B; Bignert, A; Athanassiadis, I; Bergman, A
2015 | Environ. Sci. Technol. | 49 (8) (5107-5114)
Serum from 82 individual cats was analyzed for decabromobiphenyl (BB-209), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and 2,4,6-TBP in order to study differences in body burden between healthy and sick cats diagnosed with Feline Hyperthyroidism (FH). Within the study group, 60 of these cats had a euthyroid (n = 23) or hyperthyroid (n = 37) status, all of which were used in the comparison. This study shows that hyperthyroid compared to euthyroid cats have higher serum concentrations for some of the investigated PBDEs (BDE-99, BDE-153, and BDE-183) and CB-153 on a fat weight basis. Further, it is intriguing, and beyond explanation, why the flame retardant BB-209 (discontinued in 2000) is present in all of the cat serum samples in concentrations similar to BDE-209. Median BDE-47/-99 ratios are 0.47 and 0.32 for healthy and euthyroid cats, respectively, which differs significantly from Swedes, where the ratio is 3.5. Another important finding is the occurrence of very low levels or the absence of hydroxylated PBDE metabolites in the cats. In addition, the major OH-PBDE, 6-OH-BDE47, is likely of natural origin, probably ingested via cat food. The statistics indicate an association between elevated PBDE concentrations in the cats and PH.

Brominated flame retardant exposure of aircraft personnel

Strid, A; Smedje, G; Athanassiadis, I; Lindgren, T; Lundgren, H; Jakobsson, K; Bergman, A
2014 | Chemosphere | 116 (83-90)
The use of brominated flame retardants (BFRs) such as polybrominated diphenyl ethers (PBDEs) in aircraft is the result of high fire safety demands. Personnel working in or with aircraft might therefore be exposed to several BFRs. Previous studies have reported PBDE exposure in flight attendants and in passengers. One other group that may be subjected to significant BFR exposure via inhalation, are the aircraft maintenance workers. Personnel exposure both during flights and maintenance of aircraft, are investigated in the present study. Several BFRs were present in air and dust sampled during both the exposure scenarios; PBDEs, hexabromocyclododecane (HBCDD), decabromodiphenyl ethane (DBDPE) and 1,2-bis (2,4,6-tribromophenoxy) ethane. PBDEs were also analyzed in serum from pilots/cabin crew, maintenance workers and from a control group of individuals without any occupational aircraft exposure. Significantly higher concentrations of PBDEs were found in maintenance workers compared to pilots/cabin crew and control subjects with median total PBDE concentrations of 19, 6.8 and 6.6 pmol g(-1) lipids, respectively. Pilots and cabin crew had similar concentrations of most PBDEs as the control group, except for BDE-153 and BDE-154 which were significantly higher. Results indicate higher concentrations among some of the pilots compared to the cabin crew. It is however, evident that the cabin personnel have lower BFR exposures compared to maintenance workers that are exposed to such a degree that their blood levels are significantly different from the control group. (C) 2014 Elsevier Ltd. All rights reserved.

Changes in serum concentrations of polychlorinated biphenyls (PCBs), hydroxylated PCB metabolites and pentachlorophenol during pregnancy

Glynn, A; Larsdotter, M; Aune, M; Darnerud, PO; Bjerselius, R; Bergman, A
2011 | Chemosphere | 83 (144-151)

Reductive debromination of nonabrominated diphenyl ethers by sodium borohydride and identification of octabrominated diphenyl ether products

Granelli, L; Eriksson, J; Athanasiadou, M; Bergman, A
2011 | Chemosphere | 82 (839-846)

Brominated and Chlorinated Flame Retardants: The San Antonio Statement (vol 118, pg A514, 2010)

Birnbuam, LS; Bergman, A
2011 | Environ. Health Perspect. | 119 (A11-A11)

Flame Retardants in Airplanes

Smedje, G; Lindgren, T; Jakobsson, K; Athanassiadis, I; Bergman, A
2011 | Epidemiology | 22 (1) (S80-S80)

San Antonio Statement on Brominated and Chlorinated Flame Retardants (vol 118, pg A516, 2010)

DiGangi, J; Blum, A; Bergman, A; Dewit, C; Lucas, D; Mortimer, D; Schecter, A; Scheringer, M; Shaw, S; Webster, T
2011 | Environ. Health Perspect. | 119 (A11-A11)

A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden

Sundstrom, M; Ehresman, DJ; Bignert, A; Butenhoff, JL; Olsen, GW; Chang, SC; Bergman, A
2011 | Environ Int | 37 (178-183)

Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study

Hertz-Picciotto, I; Bergman, A; Fangstrom, B; Rose, M; Krakowiak, P; Pessah, I; Hansen, R; Bennett, DH
2011 | 10

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