Inter-comparison of personal monitors for nanoparticles exposure at workplaces and in the environment

Todea, A. M.; Beckmann, S; Kaminski, H.; Bard, D.; Bau, B.; Clavaguera, S.; Dahmann, D.; Dozol, H.; Dziurowitz, N.; Elihn, K.; Fierz, M.; Lidén, G.; Meyer-Plath, A.; Monz, C.; Neumann, V.; Pelzer, J.; Simonow, B. K.; Thali, P.; Tuinman, I.; van der Vleuten, A.; Vroomen, H.; Christof Asbach, C.
2017 | Sci. Total Environ. | 605-606 (929-945)

Personal monitors based on unipolar diffusion charging (miniDiSC/DiSCmini, NanoTracer, Partector) can be used to assess the individual exposure to nanoparticles in different environments. The charge acquired by the aerosol particles is nearly proportional to the particle diameter and, by coincidence, also nearly proportional to the alveolar lung-deposited surface area (LDSA), the metric reported by all three instruments. In addition, the miniDiSC/DiSCmini and the NanoTracer report particle number concentration and mean particle size. In view of their use for personal exposure studies, the comparability of these personal monitors was assessed in two measurement campaigns. Altogether 29 different polydisperse test aerosols were generated during the two campaigns, covering a large range of particle sizes, morphologies and concentrations. The data provided by the personal monitors were compared with those obtained from reference instruments: a scanning mobility particle sizer (SMPS) for
LDSA and mean particle size and a ultrafine particle counter (UCPC) for number concentration. The results indicated that the LDSA concentrations and the mean particle sizes provided by all investigated instruments in this study were in the order of ±30% of the reference value obtained from the SMPS when the particle sizes of the test aerosols generatedwerewithin 20–400 nm and the instruments were properly calibrated. Particle size, morphology and concentration did not have a major effect within the aforementioned limits. The comparability of the number concentrations was found to be slightly worse and in the range of ±50% of the reference value obtained from the UCPC. In addition, a minor effect of the particle morphology on the number concentration measurements was observed. The presence of particles >400nm can drastically bias the measurement results of all instruments and all metrics determined.

Lung function in asphalt workers: a longitudinal study

Bente Ulvestad; Britt Grethe Randem; Øyvind Skare; Trond Mogens Aaloekken; Georg Karl Myranek; Karine Elihn; May Brit Lund
2017 | Int Arch Occup Environ Health | 90 (1) (63-71)

In vitro genotoxicity of airborne Ni-NP in air-liquid interface

Siiri Latvala; Daniel Vare; Hanna L. Karlsson; Karine Elihn
2017 | J Appl Toxicol | doi 10.1002/jat.3510

Inflammatory markers and exposure to airborne particles among workers in a Swedish pulp and paper mill

Håkan Westberg; Karine Elihn; Eva Andersson; Bodil Persson; Lennart Andersson; Ing-Liss Bryngelsson; Cathe Karlsson; Bengt Sjögren
2016 | Int Arch Occup Environ Health | 85 (5) (813-822)

Optimization of an air-liquid interface exposure system for assessing toxicity of airborne nanoparticles

Siiri Latvala; Jonas Hedberg; Lennart Möller; Inger Odnevall Wallinder; Hanna L. Karlsson; Karine Elihn
2016 | J Appl Toxicol | 36 (10) (1294-1301)

Surface passivity largely governs the bioaccessibility of nickel-based powder particles at human exposure conditions

Hedberg, Y. S.; Herting, G.; Latvala, S.; Elihn, K.; Karlsson, H. L.; Odnevall Wallinder, I.
2016 | Regul. Toxicol. Pharmacol. | 81 (162-170)

Nickel Release, ROS generation and Toxicity of Ni and NiO Micro- and Nanoparticles

Siri Latvala; Jonas Hedberg; Sebastiano Di Bucchianico; Lennart Möller; Inger Odnevall Wallinder; Karine Elihn; Hanna Karlsson
2016 | PLoS ONE | 11 (7) (1-20)

Cellular Dose of Partly Soluble Cu Particle Aerosols at the Air–Liquid Interface Using an In Vitro Lung Cell Exposure System

Karine Elihn; Pontus Cronholm; Hanna L Karlsson; Klara Midander; Inger Odnevall Wallinder; Lennart Möller
2013 | J Aerosol Med Pulm Drug Deliv | 26 (2) (84-93)

Intracellular Uptake and Toxicity of Ag and CuO Nanoparticles: A Comparison Between Nanoparticles and their Corresponding Metal Ions

Pontus Cronholm; Hanna L. Karlsson; Jonas Hedberg; Troy A. Lowe; Lina Winnberg; Karine Elihn; Inger Odnevall Wallinder; Lennart Möller
2013 | Small | 9 (7) (970-982)

Characterisation of nano- and micron-sized airborne and collected subway particles, a multi-analytical approach

Klara Midander; Karine Elihn; Anna Wallén; Lyuba Belova; Anna-Karin Borg Karlsson; Inger Odnevall Wallinder
2012 | Sci. Total Environ. | 427-428 (390-400)

Effect of sonication and serum proteins on copper release from copper nanoparticles and the toxicity towards lung epithelial cells

Pontus Cronholm; Klara Midander; Hanna Karlsson; Karine Elihn; Inger Odnevall Wallinder; Lennart Möller
2011 | Nanotoxicology | 5 (2) (269-281)

Correlation between airborne particle concentrations in seven industrial plants and estimated respiratory tract deposition by number, mass and elemental composition

2011 | J Aerosol Sci | 42 (2) (127-141)
particle deposition , particle inhalation , particle size , respiratory system , size distribution , workplace measurement

The number and mass distribution of airborne particles were recorded in several
industrial plants. From the data obtained, particle deposition was estimated in three
regions of the respiratory tract using the ICRP grand average deposition model based
on Hinds’(1999) parameterization.The median diameter was 30–70 nm (number
distributions), and 4 µm (mass distributions) near most work activities, resulting in
linear relationships between the deposited number/mass concentrations and the
number/mass concentrations in theair. Welding and laser cutting produced particles
in the 200–500-nm range; total deposition was small, not in accordance with the linear relationship observed for the other work activities. The elemental content varied between particle sizes in some workplaces, causing different elements to deposit in different respiratory regions. Iron was the most abundant element in the particles in many of the workplaces; in an iron foundry, however, Fe was most abundant only in the micron-sized particles whereas the nanoparticles mainly comprised Pb and Sb.

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