The project is aiming to assess the exposure situation to anthropogenic thyroid hormone disrupting compounds (THDCs) in home environments and the mixture effects of these compounds. Indoor pet cats are being used as a model for assessing this exposure due to their high dust ingestion. Cat serum and household dust represents the internal and external exposure to these chemicals. Key emerging THDCs are searched for by in silico modelling of reported dust contaminants from the literature as well as performing chemical analysis and effect-directed analysis (EDA) on serum and dust. The toxicity, i.e. the thyroid hormone disruption potency of individual compounds and realistic mixtures of these THDCs, are being assessed and evaluated in a battery of in vitro tests and in vivo models (e.g. the frog model and the zebrafish embryo model).
The overall aim is to improve the understanding of human and child exposures to indoor related chemicals and their thyroidogenic effects in mixtures, which is the central hub of MiSSE. The project is aimed to feed in scientific results for improved management of EDCs.