This research project will study the intake, metabolism and elimination processes of legacy and replacement per- and polyfluoroalkyl substances (PFASs) in a unique cohort of highly exposed fishery employees around Lake Tangxun, China. The project will develop and apply state-of-the-art analytical techniques and toxicokinetic (TK) models. In combination with the elevated exposure and well defined intake route in this cohort, it is envisioned that the research will result in scientific breakthroughs which would not be possible in studies on background exposed individuals.
