The full title of the project is “Mixture assessment of Endocrine Disrupting Compounds (EDC) with emphasis on thyroidogenicity – using cats as model for human indoor exposure”. We use throughout the website the abbreviation MiSSE (Mixture aSSessments of EDCs).
The long reaching goal of MiSSE is to identify mixtures of endocrine disrupting chemicals (EDCs), with emphasis on thyroid hormone disruption in indoor environments that may lead to hormone related diseases and disorders. Identification of relevant mixtures of EDCs is essential to prevent human exposure, in particular in small children, and to enable improvements in living conditions for humans in general. Hence the ultimate goal of MiSSE is to provide the scientific basis for regulatory measures to minimize the sources of chemicals of concern.
Figure 1. Overview of the four Pillar of the proposed MISSE project, surrounding the project Hub (Mixture Assessment), each contributing to the overarching aim of mixture assessment.
The central objective of MiSSE is to perform an in depth assessment of mixtures of thyroidogenic compounds (TDCs) in the indoor environment. This objective is built on four Pillars surrounding the mixture assessment Hub, as described below and visualized in Figure 1.
The four Pillars each contributes to the Hub.
- Chemicals of Concern (CoC) will be identified, which include not only established anthropogenic toxicants but also emerging, novel and potential contaminants that may contribute to the overall toxic and/or endocrine related effects in humans and wildlife. MISSE will focus on chemicals exposure for humans, in particular small children, i.e. chemicals present in indoor materials and goods. The process for selection of CoC will include knowledge on materials chemistry, emissions, biotic/abiotic transformations of CoC, and evaluation of the contribution of unknown products to the mixture effects.
- External and Internal Exposure assessments will be performed to elucidate the complex mixture profile of emerging, novel and potential contaminants in homes by applying chemical analysis of dust and cat serum, a biomarker for human exposure to CoC.
- In depth Endocrine Disrupting Potency Evaluation of the thyroid hormone disrupting effects of individual chemicals, transformation products, and mixtures, using a battery of in vitro and in vivo assays.
- Effect-Directed Analysis (EDA) will identify key toxicants in the indoor environment using dust and cat serum extracts containing complex mixtures of contaminants. EDA will confirm if the selected CoC are actually relevant in the indoor environment, and will contribute with additional previously unrecognized toxic chemicals, as well as establish the mixture composition.
- The Mixture Assessment of TDCs is the Hub of the MiSSE project, which will be performed throughout the project with the contribution from the four integrated Pillars.